Wireless electroporation utilizes electromagnetic waves to induce pores in cells in a target volume, enabling local uptake of therapeutic molecules
Wireless electroporation utilizes electromagnetic waves to induce pores in cells in a target volume, enabling local uptake of therapeutic molecules
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Our device generates electromagnetic waves, focused to the target region.
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A therapy is supplied systemically or locally before the treatment to make the therapeutic molecules available in the target region.
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At the targeted site, electromagnetic waves are of such intensity, that cells will be electroporated, creating pores in the cell membrane.
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Through the pores, the therapeutic molecules will enter by simple diffusion. Minutes after the treatment is finalized, the pores will close, leaving the cell in a healthy state.
Wireless electroporation is buildon the fundament of an established biophysical phenomenon
Invasive electroporation is a robust and well-known transfection mechanism used since the 1960's in laboratories all over the world. The first human clinical trial using electroporation is dated back to 1993. Invasive electroporation is already used in 20 clinical trials for delivering genetic therapies.
Gene therapy needs a paradigm shift
Unlocking the true potential of gene therapy demands a fundamental change. Current limitations in delivery, effectiveness and safety are holding back the full realization of gene therapy’s disease-curing capabilities.
Existing non-viraldelivery challenges
- Low efficiency
- Temporary expression
- Material-related toxicities
- Poor targeted delivery
Viral delivery challenges
- Immunogenicity
- Complex and costly
- Tissue biodistribution
- Payload limitations
Platform advantages
Improved safety
Wireless electroporation provides enhanced specificity and eliminates immunogenicity risks, elevating the safety profile of gene therapies
Excellent translation
Electroporation is renowned for its consistent performance across cells, animals, and humans, offering a high level of predictability in drug delivery across species.
Diverse payloads
Wireless electroporation is payload agnostic, capable of delivering a wide range of molecules—from RNA and DNA to substances up to 2000 kDa—in a versatile manner.
Gentle treatment
Wireless electroporation provides enhanced specificity and eliminates immunogenicity risks, elevating the safety profile of gene therapies